her, expolde

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  • WalrusDragonOnABike [they/them]
    6•7 days ago

    https://transfemscience.org/articles/spiro-testosterone/

    These findings suggest that spironolactone has inconsistent and limited effects on testosterone levels. Moreover, these data, as well as studies of estradiol alone, indicate that estradiol is mainly responsible for lowered testosterone levels when the combination of estradiol and spironolactone is used for hormone therapy in transfeminine people. Besides testosterone suppression, spironolactone also acts as a direct antagonist of the androgen receptor, and this importantly contributes to its antiandrogenic efficacy as well. However, studies in cisgender women suggest that spironolactone is a relatively weak androgen receptor antagonist, and is likely best-suited for blocking relatively low testosterone levels.

    • sneak100 [she/her, they/them]English
      5•7 days ago

      Thanks for sharing this & helping out

      thonk I’ll need to get a different antiandrogen eventually, but I’ll go through what stock I have for now at a bit of a higher rate than before and hope for the best. Until the next blood test

      • comrade_rain [she/her]English
        4•7 days ago
        subcutaneous injections, nsfw

        I’m doing subcutaneous injections without an antiandrogen.

        Within a week my ejaculation was clear.

        Seven weeks in my testicles are back to pre-puberty size. This may have happened sooner but I noticed just last week.

        Libido is much less frustrating. Aggression in check. Boobs growing.

        I haven’t had my levels checked but so far the results are way better than I expected.

        Other people’s timelines will of course be differet. But if you can handle injections it might be another option rather than bumping or switching antiandrogens.

        A lady I know was having issues and so she had her testicles removed. That helped her a lot too.

      • WalrusDragonOnABike [they/them]
        3•7 days ago

        Its an annoy game of small tweaks and hoping things work while waiting months between tests and lots of YMMV. Feels like the science could be better too, but I don’t read primary literature in the field, so idk.