Sequoia in my ass. Yikes.

Yeah, even as a fan of biotech/synthetic biology, this gives me the heebie jeebies. I would rather serious resources be devoted to the Virtual Physiological Human Project and then have hospitals have ubiquitous dedicated bioprinters that can make organs/tissues based on genetic data from a cheek swab. Also genetic records are either temporary and needing consented reapplication or are permanent yet completely transparent about what data the hospital has and how it’s being used/stored.

I believe you are right. I should’ve been clearer in my original post, but I was envisioning getting the memories/upload state into the brain of the new body, not staying as a digital copy. My thought was that if you included memories up until the moment of death for your original self that it could be a semblance of “seamless continuation” because the clone would indeed think it is the original. However, at best, like you pointed out, it isn’t so much extension of life as replacement.

In the scheme of things, my preferences for life extension tech methods in order of “preserving the original” would be: organ replacement -> nanobots/gene tweaks -> cyborgization -> cryonics -> mind uploading to a new body

I suppose a matter replicator could advance tech in each area to make them more likely to occur though given that research would no longer have material constraints.

Beyond the easy answers of replicating the machine itself or covering basic needs, I think it would be interesting to make a super computer with a small form factor capable of mind uploading. Then you print a replacement body in a position that fits within a cubic meter and presumably you can extend your life for a bit. A simpler alternative would be to replicate medicines that have been shown to extend healthspans in the short term and just take them in the recommended dosage when you need to.

Shadowrun or Eclipse Phase, either way it’s not good. I’d like the tech from the latter, but not the rest of the setting.