Seven years have passed since the FDA gave its blessing for the Targeting Aging with Metformin (TAME) clinical trial, the first trial to target the effects of aging. TAME is a double blind, placebo-controlled, multi-center study designed to evaluate whether the diabetes drug Metformin can protect against age-related conditions such as cancer, dementia or cardiovascular disease in non-diabetic study participants. The goal of the trial is to establish an indication for aging, which the American Federation of Aging Research refers to as a “proof of concept” that aging is an appropriate drug target.