Doctors in the US have become the first to treat a baby with a customised gene-editing therapy after diagnosing the child with a severe genetic disorder that kills about half of those affected in early infancy.

KJ was born with severe CPS1 deficiency, a condition that affects only one in 1.3 million people. Those affected lack a liver enzyme that converts ammonia, from the natural breakdown of proteins in the body, into urea so it can be excreted in urine. This causes a build-up of ammonia that can damage the liver and other organs, such as the brain.

Writing in the New England Journal of Medicine, the doctors described the painstaking process of identifying the specific mutations behind KJ’s disorder, designing a gene-editing therapy to correct them, and testing the treatment and fatty nanoparticles needed to carry it into the liver. The therapy uses a powerful procedure called base editing which can rewrite the DNA code one letter at a time.

    • Nangijala@feddit.dk
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      10 hours ago

      You know what? You’re right. Let’s cancel medicine because it is eugenics. Let nature take care of those who are too weak to live. Fuck em.

      Fuck vaccines, fuck lifesaving surgery, fick meds, fuck gene-editing that can save a baby from a life of suffering due to severe genetic disorders.

      Fuck them all. We wouldn’t want to change anything for anyone because that might make some ignorant Karen think that medicine is eugenics.

    • Match!!@pawb.social
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      9 hours ago

      they aren’t even altering the kid’s gonads, just the liver, so his ability to pass on that gene is unaffected for future generations