The theme song sums it up nicely:

Way way back in the 1980’s
secret government employees
dug up famous guys and ladies
and made amusing genetic copies

Well those clones are sexy teens now
They’re gonna make it if they try
Living, learning, sharing, judging
Time to laugh and shiver and cry
Clone High!

Highlights not covered by the theme song:
Robot butler / vice principle
Narrator is called “pun dog”
The voice talents of Will Forte and Christa Miller
at some point they knew they weren’t getting a second season and went balls out